Dr Joseph CHOUKROUN

Osteo-immunology : A new paradigm shift in implantology and bone grafting

Osteoimmunology is the modern science that shows the influence of the immune system on bone metabolism but also on all tissue healing phenomena. Indeed, bone healing starts with an immune reaction: inflammation triggered by the release of inflammatory cytokines. These cytokines are responsible for angiogenesis, which activates the formation of bone callus.

The behavior of bone cells is dependent on the functioning of the immune system which depends on the level oxidants. High level production of oxidants is named oxidative stress, will lead to a failure of the immune system with collateral effects such as infection, bone resorption by stopping remodeling, or fibro-integration. This is the case, for example, in diabetics, smokers, patients allergic to penicillin or in chronic inflammatory diseases.

A favorable bone metabolism will necessarily require a reduction of oxidative stress by means of various solutions such as adequate vitamin D supplementation, reduction of LDL cholesterol levels or other adequate immune stimulants. Antibiotic prophylaxis must also be revisited in order to use antibiotics with significant immune-stimulating properties.

PRF has also an immune function : decreases the inflammatory level and increases the local anti-oxidants.

It will be easy to demonstrate that peri-implantitis is an immune disease that causes bone loss around the implant, triggered by oxidative bone stress.

MD, University of Montpellier, France 1979
Specialist in General Surgery, Anesthesiology & Pain management
Owner of Private Pain Clinic, Nice France.
President of SYFAC, international symposium on growth factors,
Inventor of the PRF techniques
Author of several scientific publications.
International speaker