Figen Seymen

Speaker Details
  • Lecture details

    Lecture Title: My Journey with Amelogenesis Imperfecta

    Prof. Dr. Figen Seymen

    Altınbaş University, Faculty of Dentistry, Department of Paediatric Dentistry, İstanbul, Türkiye

    Amelogenesis Imperfecta (AI) is a collective designation for the variety of inherited conditions displaying isolated enamel malformations, but the designation is also used to indicate the presence of an enamel phenotype in syndromes. There is great variability in the clinical presentation of amelogenesis imperfecta. The clinical features of the affected enamel and the type of AI depend on the gene involved and the relevant mutation. Clinical phenotypes display a wide spectrum, ranging from mild color changes to severe structural alterations with daily pain. However, all affect the quality of life because of mechanical, psychological, esthetic, and/or social repercussions.

    It will be possible to implement more accurate diagnostic methods and make a more precise prognosis if the clinical and radiographic appearance of the affected enamel can be correlated with the potential genetic origin of AI. The genetic control of amelogenesis is fully understood but requires the activities of multiple components that are uniquely important for dental enamel formation. Genetic studies have demonstrated the importance of genes encoding enamel matrix proteins in the etiology of isolated AI. More than 20 genes are, so far, known to be responsible for this condition. These results broaden our understanding of the molecular genetic pathology of tooth enamel formation.

    The biological processes and mechanisms leading to AI are many and varied. Further research with a molecular approach will improve our understanding of these mechanisms and identify new mutations or genes and this will result in improved patient care and the development of new therapies to minimize or eliminate the problems associated with AI.

    This lecture will focus on our research and the evidence about AI. We will review the genes and mutations underlying AI presenting in isolation from other health problems, the proteins they encode, and knowledge of their roles in amelogenesis, combining evidence from human phenotypes

    The aim of this lecture is to present an evaluation of our studies regarding the role of the genes associated with AI types.

  • CV

    Prof. Dr. Figen Seymen BIO

    Figen Seymen graduated from the Faculty of Dentistry, Istanbul University, Türkiye, and obtained a Ph.D. degree and MSc degree from the same University and became a Pediatric Dentistry Professor at Istanbul University Faculty of Dentistry in 2002. She has over 34 years of experience in Academics in all aspects of dental education, didactic, clinical/patient care, and research mentoring for MS and Ph.D. students. She has lectured as an invited speaker and has participated in many presentations at congresses and continuous education courses. She is a member of various International Scientific Societies and Associations.

    Between 2014 and 2017 she was the head of the Department of Paediatric Dentistry at Istanbul University. In 2014 she was elected as President of the Turkish Society of Paediatric Dentistry and still she is continuing to serve as the President. She served as President of the Association of Mediterranean Societies of Pediatric Dentistry between 2014-2018 and still serves as a member of the Board of Directors. She was Councilor of the European Academy of Paediatric Dentistry (EAPD) between 2012-2018 and then held the following position: a member of the Credentials Committee. She served as a member of the Membership Committee of IAPD between 2017-2019. She began to serve as a Board member of the International Association of Paediatric Dentistry (IAPD) in 2019 and held the position of Chair of the Education Committee and Representative of the Nations between 2019 to 2021. She was elected as President-Elect of IAPD in 2021 and she began to serve as President of IAPD in June 2023. She is on the Advisory Board and Editorial Board of several international and national journals and published over 300 research articles co-authored several book chapters and obtained research grants.

    Prof. Dr. Figen Seymen has been working in all fields of pediatric and preventive dentistry, and especially enamel anomalies, dental anomalies, genetics, syndromes, and aesthetic treatments of tooth anomalies are among her special interests.

    She worked at Istanbul University Paediatric Dentistry from 1987-2022. In February 2022 she was appointed Chair and Program Director at the Department of Pediatric Dentistry of Altınbas University.

Speaker Details
  • Lecture details

    Lecture Title: My Journey with Amelogenesis Imperfecta

    Prof. Dr. Figen Seymen

    Altınbaş University, Faculty of Dentistry, Department of Paediatric Dentistry, İstanbul, Türkiye

    Amelogenesis Imperfecta (AI) is a collective designation for the variety of inherited conditions displaying isolated enamel malformations, but the designation is also used to indicate the presence of an enamel phenotype in syndromes. There is great variability in the clinical presentation of amelogenesis imperfecta. The clinical features of the affected enamel and the type of AI depend on the gene involved and the relevant mutation. Clinical phenotypes display a wide spectrum, ranging from mild color changes to severe structural alterations with daily pain. However, all affect the quality of life because of mechanical, psychological, esthetic, and/or social repercussions.

    It will be possible to implement more accurate diagnostic methods and make a more precise prognosis if the clinical and radiographic appearance of the affected enamel can be correlated with the potential genetic origin of AI. The genetic control of amelogenesis is fully understood but requires the activities of multiple components that are uniquely important for dental enamel formation. Genetic studies have demonstrated the importance of genes encoding enamel matrix proteins in the etiology of isolated AI. More than 20 genes are, so far, known to be responsible for this condition. These results broaden our understanding of the molecular genetic pathology of tooth enamel formation.

    The biological processes and mechanisms leading to AI are many and varied. Further research with a molecular approach will improve our understanding of these mechanisms and identify new mutations or genes and this will result in improved patient care and the development of new therapies to minimize or eliminate the problems associated with AI.

    This lecture will focus on our research and the evidence about AI. We will review the genes and mutations underlying AI presenting in isolation from other health problems, the proteins they encode, and knowledge of their roles in amelogenesis, combining evidence from human phenotypes

    The aim of this lecture is to present an evaluation of our studies regarding the role of the genes associated with AI types.

  • CV

    Prof. Dr. Figen Seymen BIO

    Figen Seymen graduated from the Faculty of Dentistry, Istanbul University, Türkiye, and obtained a Ph.D. degree and MSc degree from the same University and became a Pediatric Dentistry Professor at Istanbul University Faculty of Dentistry in 2002. She has over 34 years of experience in Academics in all aspects of dental education, didactic, clinical/patient care, and research mentoring for MS and Ph.D. students. She has lectured as an invited speaker and has participated in many presentations at congresses and continuous education courses. She is a member of various International Scientific Societies and Associations.

    Between 2014 and 2017 she was the head of the Department of Paediatric Dentistry at Istanbul University. In 2014 she was elected as President of the Turkish Society of Paediatric Dentistry and still she is continuing to serve as the President. She served as President of the Association of Mediterranean Societies of Pediatric Dentistry between 2014-2018 and still serves as a member of the Board of Directors. She was Councilor of the European Academy of Paediatric Dentistry (EAPD) between 2012-2018 and then held the following position: a member of the Credentials Committee. She served as a member of the Membership Committee of IAPD between 2017-2019. She began to serve as a Board member of the International Association of Paediatric Dentistry (IAPD) in 2019 and held the position of Chair of the Education Committee and Representative of the Nations between 2019 to 2021. She was elected as President-Elect of IAPD in 2021 and she began to serve as President of IAPD in June 2023. She is on the Advisory Board and Editorial Board of several international and national journals and published over 300 research articles co-authored several book chapters and obtained research grants.

    Prof. Dr. Figen Seymen has been working in all fields of pediatric and preventive dentistry, and especially enamel anomalies, dental anomalies, genetics, syndromes, and aesthetic treatments of tooth anomalies are among her special interests.

    She worked at Istanbul University Paediatric Dentistry from 1987-2022. In February 2022 she was appointed Chair and Program Director at the Department of Pediatric Dentistry of Altınbas University.