Dimitrios Andreadis

Oral Region, New Vision: Shedding Light on the Consequences of Cancer Immunotherapy in the oral mucosa

Oral immune-related adverse events (irAEs) are a growing clinical concern in oncologic patients receiving immune checkpoint inhibitors (ICIs)-targeted immune therapy. These adverse events can manifest across a spectrum of oral conditions, including mucositis, xerostomia, and autoimmune-related ulcerations or bullous lesions, with potential to significantly impact patient morbidity and treatment outcomes. Despite their clinical relevance, oral irAEs remain underrecognized, with limited standardized guidelines for management. This presentation will examine the pathophysiological mechanisms underlying oral irAEs, focusing on the immune-mediated alterations of the oral mucosa and associated tissues. We will discuss the latest advances in diagnosis, risk factors, and the evidence supporting various therapeutic approaches. Emphasis will be placed on early detection and multidisciplinary management strategies, integrating dental and medical care to optimize patient outcomes. By reviewing current literature and clinical cases, this session aims to provide healthcare professionals with a comprehensive understanding of oral irAEs and actionable strategies for their effective management.

Andreadis Dimitrios, DDS, MA, PhD,
Associate Professor of Oral Medicine/Pathology
Department of Oral Medicine/Pathology
School of Dentistry, Aristotle University of Thessaloniki, Greece

Dimitrios Andreadis is Associate Professor of Oral Medicine at the School of Dentistry, Aristotle University of Thessaloniki (AUTH), where he previously served as Lecturer (2009–2015) and Assistant Professor (2015–2021). Since 2017, he has been a Scientific Collaborator–Consultant at the 2nd University Dermatology Clinic, AUTH Medical School, Papageorgiou Hospital, Thessaloniki, Greece. He earned his DDS (1998) and PhD in Oral Medicine (2004) from AUTH and completed advanced training at the Oral Medicine Department of the University Dermatology Clinic, National and Kapodistrian University of Athens (A. Syggros Hospital), as well as at the Molecular Biology Laboratory, Dental Department, Hannover, Germany. He also holds an MA in Bioethics (2024) from the Open University of Cyprus, Department of Social and Human Sciences. He has experience in clinical and laboratory diagnosis of oral diseases, and his research encompasses oral cancer/precancer, mucosal drug delivery, autoimmune oral/skin bullous diseases, oral and salivary gland stem cells, cancer stem cells, and bioethics in clinical practice. He has authored over 100 publications and delivered more than 200 presentations at national and international journal and conferences, respectively.