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Dr. Boris Simončič
Speaker Details
- Lecture details
Stem Cells In Regenerative Dentistry
Simončič B*, Vulićević ZR, Marković DThe use of Mesenchymal Stem Cells (MSC) and MSC identycal Dental Pulp Stem Cells (DPSC) became one of the most interesting tools in regenereative dentistry. These are pluripotent cells which could differentiate in all tissue cells, axcept embrional. We can use them for regenerative therapies in endodontology, periodontology, maxillofacial and orall surgery as well. Our »in vitro« experiences about their differential capabilities show on possible use in bone tissue ingeneering, culturing of dental pulp like tissues, angiogenesis etc. The abilities of these cells for proliferation and differentiation are outstanding.
We have evaluated the potential differentiation of adipose derived MSC's into adipose and bone lines as well. Tissue and Cell banks enhance biodeposit in part of cell processing and create a basement for developing different methodes of therapies in dentistry. All processed cells and tissues are, according to EU legislation, treated as Advanced Therapy Medicinal Product (ATMP). To follow these directions, our group has developed special protocols for collecting and storing the dental and adipose tissues for processing, cultivation and therapy purposes. Collected tissues undergo cryopreservation, thoroughly overwiuved by EU inspection organs, for further use in regenerative dental therapies.
Adipose derived MSC and DPSC show a signifficant potential for tissue regeneration and several chronical deseases treatment as well. Speciffic MSC show higher succsses rate in therapy results as all collected MSC. However, further clinical research is needed in this field of regnerative dentistry.
- CV
Academic and Professional qualiffications:
1985 Dental Faculty (Medical Faculty, Uni at Ljubljani, Dep for Dentistry)
1993 Specialization of Dental and Oral Diseases and Periodontics (MF of University of Ljubljana, Dentistry department)
1993 Degree in Oral Rehabilitation with integrated osteoprotesis (EOTC, Leuven, Belgija)
1995 Degree in Bioresonance Therapy BICOM technology (Brὒgemann Institut, Munich, Germany)
1999 PhD in Stomatology (Ludwig Maximillian University, Munich, Fermany)
2000 Degree in Clinical Periodontology and Dental Implantology (Ian Lindhe, Novodent, Croatia)
2004 Degree in Interactive Neurostimulation Inter X 5000 (Neuro Resource Group, Cheltenham, GB)
2021 Visiting Professor for Regenerative Medicine by means of Stem cells, Faculty of Stomatology, University of Beograd, Serbia
Employment:
1991 Assistant professor of Department of Oral Diseases and, MF University of Ljubljana, Stomatology Department
1993 Simed d.o.o., private clinic, Ljubljana
Science fields
Periodontology, Implantology, Dental Materials, Treatment of acute and chronic pain with neurostimulation, Regenerative therapy with Stem cells, Aplaing of Personal detecting sensors for long term monitoring
Awards and recognitions
2016 Honor of Jožef Stefan Institute, Lju0bljana, Slovenija: Transfer of science and technology from Institute to Industry in Slovenia and Worldwide
2016 Paul Harris Fellow, Rotary International, Contribution to good international relations
Administration
1991 Associate Asistant in Dental Composite Development, Haraeus Kulzer, Bad Homburg, Germany
1992 Member of Oral Diseases and Periodontics society, Ljubljana, Slovenija
1992 Member of Dental Diseases and Endodontics society, Ljubljana, Slovenia
1993 Founder and president of Slovenian Society of Osteointegration, Ljubljana, Slovenia
1993 Member of European Society of Osteointegration
1994 Member of European Federation of Periodontology
1995 Member of European Federation of Endodontics
International collaborations
1991 – Associate Asistent in development of dental composite on the research department of u Haraeus Kulzer, Germany. Working on the field of clinical research for composite structure change with the aim of better adaptation in tooth cavity, less abrasive surface and broad specter of composite colour.
1998 – Science associate of LM Uni, Munich, Germany, working on development of 3D computerized laser development for determination of abrassion level of dental material in oral cavity
2006 – University of Genova, Department of Stomatology, working as Study Associate Asistent with Prof. Dr. Sc. U. Covani study group: Measerment of a force needed for a fracture of a dental implant abutment screw
2018 – Development of appliance for stem cells separation from tissue sample, which is based on proprietary technology of selective membrane covered with humanized antibodies. In collaboration with Bio- recell LtD, London; L-Tek Slovenija; MF Uni of Maribor, Slovenia; and Medical Centar Mirje, Slovenia
2019 – Development of humanized antibodies for isolation of pure stem cells from tissue sample. In collaboration with Bio-recell, London, GB; Biotem, Custom Antibodies & Services, Apprieu Francuska, Medical Centar Mirje, Ljubljana, Slovenija.
2020 – Faculty od Dentistry, University of Beograd, Srbia. Study and research collaboration on the use of stem cells in medicine
2020 – State of Serbia Health Insurance Department: Study and research collaboration on the use of stem cells in medicine
List of publications – Boris Simončič
Book chapters1. Simončič B, Kosanović D. (2019) The possibility of pulpitis treatment with stem cells regenerative medicine: Endodontic Therapy of Young Permanent Teeth. Praktikum. Vulićević ZR, Radović I. University of Belgrade. Faculty for Stomatology.
2. Simončič B, Kosanović D. (2021) Use of stem cells in pediatric and adolescence surgary: Oral-surgery interventions at children and teenagers. Book. Vulićević ZR, Čolić SB, Mandić JČ. University of Belgrade. Faculty for Stomatology.
Working Experiences:
Since 1999 he is an international speaker at the Congresses worldwide, such as IADR, AADR, EAO, ICRPS and at the Congresses in Slovenia as well. He has published over 20 original scientific and
overview articles. As an active participant he has given more than 25 lectures and 15 invited lectures at the International Scientiffic and Slovenian dental congresses as well. Has given 3 lectures and presented 2 posters on 5 IADR Congresses, lecturer and presenter of posters at the EAO Congress and has presented posters on Europerio 3, 4, 5, 6, 7, 8. He has given a lecture as the invited speaker at the ANDI Congress Alpe Adria in Italy, lecturer at the World Academy for Osseointegration in Venice 2006, Italy and invited speaker at the Dental Congress of Vojvodina 2011, invited speaker on BASS Congress in Skopje, Macedonia in 2013, invited speaker at the Congress of Oral Surgeons of SR Serbia in 2013.Current Preocupations:
Aim of the integration of medical field, cell technology and e-medicine. Future patient care will need more complex methods. Dr. Simoncic is working on the model of integrating different medical techniques. Modern and high tech medical practice joining with stem cell technology and bio laboratories and further patient care with e-medical devices. Thus ensure patient to establish his health and help him with optimal follow up support.
Speaker Details
- Lecture details
Stem Cells In Regenerative Dentistry
Simončič B*, Vulićević ZR, Marković DThe use of Mesenchymal Stem Cells (MSC) and MSC identycal Dental Pulp Stem Cells (DPSC) became one of the most interesting tools in regenereative dentistry. These are pluripotent cells which could differentiate in all tissue cells, axcept embrional. We can use them for regenerative therapies in endodontology, periodontology, maxillofacial and orall surgery as well. Our »in vitro« experiences about their differential capabilities show on possible use in bone tissue ingeneering, culturing of dental pulp like tissues, angiogenesis etc. The abilities of these cells for proliferation and differentiation are outstanding.
We have evaluated the potential differentiation of adipose derived MSC's into adipose and bone lines as well. Tissue and Cell banks enhance biodeposit in part of cell processing and create a basement for developing different methodes of therapies in dentistry. All processed cells and tissues are, according to EU legislation, treated as Advanced Therapy Medicinal Product (ATMP). To follow these directions, our group has developed special protocols for collecting and storing the dental and adipose tissues for processing, cultivation and therapy purposes. Collected tissues undergo cryopreservation, thoroughly overwiuved by EU inspection organs, for further use in regenerative dental therapies.
Adipose derived MSC and DPSC show a signifficant potential for tissue regeneration and several chronical deseases treatment as well. Speciffic MSC show higher succsses rate in therapy results as all collected MSC. However, further clinical research is needed in this field of regnerative dentistry.
- CV
Academic and Professional qualiffications:
1985 Dental Faculty (Medical Faculty, Uni at Ljubljani, Dep for Dentistry)
1993 Specialization of Dental and Oral Diseases and Periodontics (MF of University of Ljubljana, Dentistry department)
1993 Degree in Oral Rehabilitation with integrated osteoprotesis (EOTC, Leuven, Belgija)
1995 Degree in Bioresonance Therapy BICOM technology (Brὒgemann Institut, Munich, Germany)
1999 PhD in Stomatology (Ludwig Maximillian University, Munich, Fermany)
2000 Degree in Clinical Periodontology and Dental Implantology (Ian Lindhe, Novodent, Croatia)
2004 Degree in Interactive Neurostimulation Inter X 5000 (Neuro Resource Group, Cheltenham, GB)
2021 Visiting Professor for Regenerative Medicine by means of Stem cells, Faculty of Stomatology, University of Beograd, Serbia
Employment:
1991 Assistant professor of Department of Oral Diseases and, MF University of Ljubljana, Stomatology Department
1993 Simed d.o.o., private clinic, Ljubljana
Science fields
Periodontology, Implantology, Dental Materials, Treatment of acute and chronic pain with neurostimulation, Regenerative therapy with Stem cells, Aplaing of Personal detecting sensors for long term monitoring
Awards and recognitions
2016 Honor of Jožef Stefan Institute, Lju0bljana, Slovenija: Transfer of science and technology from Institute to Industry in Slovenia and Worldwide
2016 Paul Harris Fellow, Rotary International, Contribution to good international relations
Administration
1991 Associate Asistant in Dental Composite Development, Haraeus Kulzer, Bad Homburg, Germany
1992 Member of Oral Diseases and Periodontics society, Ljubljana, Slovenija
1992 Member of Dental Diseases and Endodontics society, Ljubljana, Slovenia
1993 Founder and president of Slovenian Society of Osteointegration, Ljubljana, Slovenia
1993 Member of European Society of Osteointegration
1994 Member of European Federation of Periodontology
1995 Member of European Federation of Endodontics
International collaborations
1991 – Associate Asistent in development of dental composite on the research department of u Haraeus Kulzer, Germany. Working on the field of clinical research for composite structure change with the aim of better adaptation in tooth cavity, less abrasive surface and broad specter of composite colour.
1998 – Science associate of LM Uni, Munich, Germany, working on development of 3D computerized laser development for determination of abrassion level of dental material in oral cavity
2006 – University of Genova, Department of Stomatology, working as Study Associate Asistent with Prof. Dr. Sc. U. Covani study group: Measerment of a force needed for a fracture of a dental implant abutment screw
2018 – Development of appliance for stem cells separation from tissue sample, which is based on proprietary technology of selective membrane covered with humanized antibodies. In collaboration with Bio- recell LtD, London; L-Tek Slovenija; MF Uni of Maribor, Slovenia; and Medical Centar Mirje, Slovenia
2019 – Development of humanized antibodies for isolation of pure stem cells from tissue sample. In collaboration with Bio-recell, London, GB; Biotem, Custom Antibodies & Services, Apprieu Francuska, Medical Centar Mirje, Ljubljana, Slovenija.
2020 – Faculty od Dentistry, University of Beograd, Srbia. Study and research collaboration on the use of stem cells in medicine
2020 – State of Serbia Health Insurance Department: Study and research collaboration on the use of stem cells in medicine
List of publications – Boris Simončič
Book chapters1. Simončič B, Kosanović D. (2019) The possibility of pulpitis treatment with stem cells regenerative medicine: Endodontic Therapy of Young Permanent Teeth. Praktikum. Vulićević ZR, Radović I. University of Belgrade. Faculty for Stomatology.
2. Simončič B, Kosanović D. (2021) Use of stem cells in pediatric and adolescence surgary: Oral-surgery interventions at children and teenagers. Book. Vulićević ZR, Čolić SB, Mandić JČ. University of Belgrade. Faculty for Stomatology.
Working Experiences:
Since 1999 he is an international speaker at the Congresses worldwide, such as IADR, AADR, EAO, ICRPS and at the Congresses in Slovenia as well. He has published over 20 original scientific and
overview articles. As an active participant he has given more than 25 lectures and 15 invited lectures at the International Scientiffic and Slovenian dental congresses as well. Has given 3 lectures and presented 2 posters on 5 IADR Congresses, lecturer and presenter of posters at the EAO Congress and has presented posters on Europerio 3, 4, 5, 6, 7, 8. He has given a lecture as the invited speaker at the ANDI Congress Alpe Adria in Italy, lecturer at the World Academy for Osseointegration in Venice 2006, Italy and invited speaker at the Dental Congress of Vojvodina 2011, invited speaker on BASS Congress in Skopje, Macedonia in 2013, invited speaker at the Congress of Oral Surgeons of SR Serbia in 2013.Current Preocupations:
Aim of the integration of medical field, cell technology and e-medicine. Future patient care will need more complex methods. Dr. Simoncic is working on the model of integrating different medical techniques. Modern and high tech medical practice joining with stem cell technology and bio laboratories and further patient care with e-medical devices. Thus ensure patient to establish his health and help him with optimal follow up support.
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