Adjunct Professor DANIEL S.OH

The raising standard in bone regeneration

Authors: Daniel S Oh, Ettore Marini, Philip Y Kang, Antonello Maria Messina

To secure implants placement for full denture rehabilitation, a solid bone is essential. When a prompt and uniform blood circulation follows on implanted bone grafts, there is a high expectation for healthy bone regeneration. Current methods for bone regeneration display a shortcoming for greater fluid absorption and healthier bone generation and recovery. InRoad® allows for the formation of stronger and healthier solid bones with implant placements, and projects a novel and efficient way of doing so. The aim is to introduce membrane-free bone reconstruction techniques using synthetic bone grafts, which has a superior sucking property via a macro-micro-nano engineered structure mixed with homologous fibrin glue (HFG).

The unique structure of novel synthetic bone grafts induced capillary action during mixing and grafting, resulting in enhanced bone regeneration. Implanted grafts were well-positioned and maintained at the defected sites even without membrane coverage. No pain or swelling was reported. 2-3 weeks following surgery, a pink mucosa covered the surgical area without inflammation. X-ray examination revealed a progressive increase in bone density. Bone density became similar to that of the adjacent healthy bone at 5–6 months. Implant insertion torques were measured up to 70 Ncm. A few fibrils and mononuclear cells and no visible inflammatory cells were confirmed by histology.

EDUCATION:
1990 B.S. Ceramic Engineering, Yonsei University, Seoul, South Korea
1995 M.S. Materials Science and Engineering, Yonsei University, Seoul, South Korea
2003 Ph.D. Materials Science and Engineering, Yeungnam University, Gyeongsan, South Korea
Dissertation Title: Synthesis of Calcium Metaphosphate for Implant Coating and Evaluation of Biocompatibility

PROFESSIONAL POSITIONS:
2003 – 2006 | Post-Doctoral Fellow | Department of Biomedical Engineering University of Tennessee Health Science Center Memphis, Tennessee
2006 – 2011 | Assistant Professor | Department of Biomedical Engineering, UTSA
2008 – 2011 | Graduate Faculty | U. of Texas Health Science Center at San Antonio
2008 – 2011 | Affiliated Professor | Interactive Technology Experience Center, UTSA
2011 – 2017 | Assistant Professor | Department of Orthopedic Surgery & College of Dental Medicine, Columbia University
2018 – 2019 | Adjunct Professor | Department of Orthopedic Surgery Columbia University
2018 – | Adjunct Professor |Department and Research Institute of Dental Biomaterials and Bioengineering Yonsei University, Seoul, Korea
2018 – | VP/Chief Science Office | OsteoGene Tech
2020 – | VP/Chief Science Office | OsteoGene Bio

OTHER PROFESSIONAL EXPERIENCE:
2016 – 2021 | President | MERCI (non-profit charitable organization: www.meci-world.org)

AREAS OF RESEARCH INTEREST:

• Bone-Like Scaffold for Regenerative Medicine
• Localized Drug Delivery Systems
• 3D Cancer Culture Model for Chemotherapeutic Agents Test
• Modeling of Skeletal Organoid
• Etiological Factors of NCCLs (noncarious cervical lesions) and Restorations

HONORS AND AWARDS:
2005 Tennessee Biomedical Engineering Conference, Research Award
2007 American Association for Dental Research, Unilever Hatton Award
2010 Academy of Osseointegration, Best Scientific Poster Presentation
2011 Academy of Osseointegration, Best Scientific Poster Presentation
2012 Society for Biomaterials, Session Organizer, “Microenvironments for osteogenesis and vasculogenesis - physical, chemical, and biological perspectives”.
2013 Keynote Address, IADR/AADR General Session; Scaffold and Bone Regeneration
2013 Keynote Speaker, Korean Society for Biomaterials
2016 International Association for Dental Research, General Session Organizer on
2018 “Microenvironments for Mineralized Tissue Engineering” Invited Speaker, 7th International Conference on Biomedical Engineering and
2019 Biotechnology, Nanjing, China. Invited Speaker/Organizing Program Committee, 8th International Congress of The Croatian Society of Dental Implantology, Split, Croatia.
2015 – present. Editorial Board: Korean Journal of Dental Materials

Journal (referenced; full length): 64 Conference Presentations & Abstracts: 98

PROFESSIONAL ACTIVITIES
Grants Review Panels
Multidisciplinary Research Grants (MRG) Program – North Carolina Biotechnology Center (2012)
Medical Research Council (MRC): United Kingdom
- Translational Stem Cell Research Committee (2013)
- Regenerative Medicine Research Committee (2015)
Department of Defense, Scientific Review Panel on PRMRP program (2014 - 2019)
Department of Defense, Scientific Review Panel on MRMC program (2015 - 2016)
Department of Defense, Chair of Scientific Review Panel on DIS-NMBR PRMRP program (2019)
Department of Defense, Scientific Review Panel on PRMRP program (2021)

Reviewer for Journals/Conference
Acta Biomaterialia; Ceramics International; Journal of Biomedical Materials Research Part A & B; Journal of Tissue Engineering and Regenerative Medicine; Journal of Non-Crystalline Solids; Artificial Organs; Surface & Coatings Technology; Materials Letters; Thin Solid Films; Surface and Interface Analysis; Connective Tissue Research; Society for Biomaterials

Professional Societies
American Society for Testing and Materials International (ASTM International)
- F04 Committee (Medical and Surgical Materials and Devices)
Society for Biomaterials
Biomedical Engineering Society
Orthopaedic Research Society
Academy of Osseointegration
American Society for Bone Mineral Research
American Association for Dental Research
International Association for Dental Research>
European Association for Osseointegration

ADDRESS:
OSTEOGENE TECH (www.osteogene.com) 70 Oak Street
Norwood, NJ 07648
Tel: (551) 214-7788 (cell) / (201) 367-9321 (work)
e-mail: danielsunho@gmail.com; dr.oh@osteogene.com