Assoc. prof. dr. Daniela Veleska-Stevkovska

OSTEOIMMUNOLOGY AND MICROBAL LOAD OF DENTAL IMPLANTS

The search of a link between the cytokine levels and the specific bacterial pathogens is the subject of new studies in osteoimmunology. Bacteria impact similar responses to the host, causing the characteristic effects of signaling pathways associated with a series of proinflammatory cytokines.

Two weeks after setting the prosthesis suprastructure by using the swab method, a part of the supragingival plaque was collected. A sample of the subgingival plaque was adsorbed on sterile dry paper strips. One year after the functional loading of implants clinical examinations were carried out to evaluate the fitness of the peri-implant tissues. Using radiographic findings the status of the alveolar bone was evaluated and the bone support was monitored. With the help of microbiological tests the implants microorganisms loading was determined.

In the evaluation of the immune status (proinflammatory and anti-inflammatory cytokine profile) and the loading with oral microorganisms on the peri-implant tissues, a statistically highly significant relationship was concluded in terms of the given time dimension of the study ("time dependent status"). In determining the correlation between immunological and microbiological status and the clinical condition of the peri-implant tissues, we determined statistically significant relationships with all the analyzed categories of parameters.

The analysis of cytokine profile contributes to the detection of early metabolic and biochemical lesions of the peri-implant tissue and monitoring the osseointegration process and the bone response to the prosthetic loading. These facts are the base of the development of future diagnostic biomarkers that will allow monitoring of the condition of the peri-implant tissues that simultaneously participate in creating strategies for early prevention and / or treatment of initial lesions of the same.

Key words: oral microorganisms, cytokines, dental implants, marginal bone loss, microbal load

Assoc. prof. Daniela Veleska-Stevkovska was born in 1976, december 9th, in Skopje. She was employed at the Clinic of oral surgery at University Dental Clinical Centar ,,St.Pantelejmon” in 2001. She completed her specialist studies in oral surgery in 2006, while she completed her subspecialist studies in oral implantology in october 2009. She holds a master's degree from 2008, while the doctoral thesis successfully defended in 2013 in Skopje and was officially promoted as doctor of dental sciences in the same year. She was selected as a assistant at the Department of oral surgery at the Faculty of Dentistry in Skopje in 2008. She was re-elected as an assistant in 2011. She was elected as a scientific associate in 2014 and assoc.professor in march 2019. As an author and co-author, she produced over one hundred scientific works, most of them published in relevant journals and presented at domestic and international congresses. She takes active participation in student congresses as a mentor on student topics. She participated in the preparation of a monograph and contributes in the publications of the Dental Faculty in Skopje and the publications of the Dentistry Chamber of north Macedonia. Since november 2013 she has been elected for membership in the board of directors and the scientific board of the Association of oral surgeons, a member of the Dental Society of North Macedonia. She becomes President of the Association of oral surgeons in December 2021.